| abstract |
The γ-type, ω-type and ν-type new compounds of the macrocyclic polyene antifungal amphotericin B of the present invention have less hygroscopicity, better storage stability, and are more conducive to the quality control of drugs and preparations, etc. Suitable for preparing infections: Cryptococcosis, North American blastomycosis, disseminated candidiasis, coccidioidomycosis, histoplasmosis, mucormycosis, sporotrichosis, aspergillosis, chromomycosis, burns The application of medicines for the treatment or prevention of post-burn skin fungal infection, respiratory Candida, Aspergillus or Cryptococcus infection, fungal corneal ulcer, fever black disease, enterovirus infection, antidepressant, etc. |