| abstract |
The invention belongs to the technical field of medicinal chemistry, and particularly provides a green refining method of isosorbide mononitrate. According to the method, isosorbide mononitrate solid is used as a raw material, and the isosorbide mononitrate rod-shaped crystal is prepared by optimizing a crystallization solvent system and accurately controlling process parameters. The method has the advantages that the usage amount of the organic solvent is greatly reduced, the energy consumption is reduced, the working operation is simple, the rod-shaped crystal prepared by the crystallization process greatly shortens the preparation filtration time, the drying time and the like of isosorbide mononitrate, improves the fluidity of the product, and is suitable for industrial mass production. |