http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112174862-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-08 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C319-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-70 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C319-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C321-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C321-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C321-14 |
| filingDate | 2020-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112174862-B |
| titleOfInvention | A kind of synthetic method of benzyl sulfide |
| abstract | Currently, there are many sulfur-containing drugs on the market for the treatment of various diseases, such as the antipsychotic drug chlorpromazine. Among them, thioethers have a wide range of biological activities. Not only is it easily converted to other types of sulfur-containing organic compounds, but it is also an important intermediate in the synthesis of many drugs. This patent discloses a method for synthesizing thioether without metal catalysis: in acetonitrile solution, benzyl trifluoromethane sulfonic acid quaternary ammonium salt and β-sulfinyl ester under the action of KOH, through the cleavage of carbon-nitrogen bond, Formation of carbon-sulfur bonds to synthesize benzyl sulfides in good to excellent yields over a wide range of substrates. In the reaction involving chiral quaternary ammonium salts, chiral thioethers are obtained with very good chiral value retention. The method has the advantages of mild reaction conditions, simple experimental operation, no metal catalyst, high product yield, wide substrate applicability, and high chiral retention value. |
| priorityDate | 2020-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 87.