http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112156189-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ea61bfc1125f5d765baa56a4d55c1d51 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0057 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6907 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6855 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-337 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2020-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_140d497a4a92e266c08aa65978384e85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_829be6fbcd2df4b59e49914378a0ed23 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8257246364ad26c06dcc246cd0b70c20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e966144bc0b24e3f90e734271a98017 |
| publicationDate | 2021-01-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112156189-A |
| titleOfInvention | A kind of HER2+ breast cancer targeting protein composite nanoparticle and its preparation method and application |
| abstract | The invention discloses a HER2+ breast cancer targeting protein composite nanoparticle and a preparation method and application thereof. The HER2+ breast cancer targeting protein composite nanoparticle is a micelle loaded with a cross-linked complex of ER antibody and recombinant p53 protein. , the micelle is formed by activation of HER2 antibody and covalent cross-linking of phycocyanin, and then cross-linking with paclitaxel through an ester bond. The p53 composite protein nanoparticles successfully synthesized in the present invention can be targeted into HER2-positive breast cancer cells, increase the concentration of P53 protein closely related to the process of apoptosis in breast cancer cells, and change the expression of related proteins caused by P53 gene mutation It also overcomes the problem of low expression of exogenous genes in cancer cells in gene therapy, and solves the problems of cell canceration and metastasis caused by P53 gene mutation. |
| priorityDate | 2020-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 127.