| abstract |
Disclosed herein are fusion proteins comprising: (a) a first polypeptide comprising interleukin-2 (IL2); and (b) a second polypeptide fused in-frame to the first polypeptide, wherein the second polypeptide The polypeptide comprises the extracellular domain of interleukin-2 receptor alpha (IL2Rα), wherein IL2 or IL2Rα contains at least one less glycosylation site than native IL2 or native IL2Rα. Methods of production and therapeutic use of the fusion proteins are also disclosed. |