http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112142830-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-552 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10234 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10222 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-235 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-34 |
| filingDate | 2020-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112142830-B |
| titleOfInvention | Recombinant avian adenovirus type 4fiber2 protein and preparation method and application thereof |
| abstract | The invention discloses a recombinant avian adenovirus type 4 (FAdV-4) fiber2 protein, a preparation method and application thereof, and belongs to the technical field of genetic engineering, wherein the recombinant protein is obtained by recombining an avian adenovirus type 4fiber2 protein with amino acid sequences from 21 st to 55 th sites of avian adenovirus type 4hexon protein after 274 amino acid residues at the N-terminal are removed, and can be used for preparing an avian adenovirus type 4 genetic engineering subunit vaccine. Aiming at the defects of poor solubility and immunogenicity of prokaryotic expression natural fiber2 protein, the invention carries out series modification on fiber2 protein coding gene, and the solubility and the immunogenicity of recombinant protein are obviously improved compared with the fiber2 protein before modification by removing the gene coding sequence of 274 amino acid residues at the N end of the fiber2 protein and fusing the gene coding sequences of two important epitope of the hexon protein, so that the recombinant protein can be used for preparing a subunit vaccine which has controllable quality, is safe and effective, can prevent highly pathogenic FAdV-4 virus infection, and can obtain complete protection by immunization once. |
| priorityDate | 2020-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 171.