http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112142823-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-81 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06026 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-062 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-02 |
| filingDate | 2019-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112142823-B |
| titleOfInvention | A kind of synthetic method of ZP-1609 |
| abstract | The invention discloses a method for synthesizing ZP-1609, comprising the following steps: 1) selectively reacting 4-amino L-proline tert-butyl ester with N-hydroxysuccinimide benzoate to complete the reaction to obtain Intermediate product; 2) linking Boc-Gly-OH with 1) gained intermediate product by DCC/HOBT liquid-phase amide condensation method to obtain intermediate product; 3) 2) obtained intermediate product is hydrolyzed to remove the protecting group-Boc of glycine with hydrochloric acid and the protecting group-tBu of the carboxyl group of proline, and further acidified with hydrochloric acid to obtain ZP-1609. In the present invention, the initial raw material is 4-amino L-proline tert-butyl ester with exposed amino terminal, which is selectively reacted with an amidating reagent, thereby shortening the synthesis steps, the process is simple in operation, convenient in post-processing, and does not require further N-terminal protection; the protecting groups ‑Boc and ‑tBu are both unstable under acidity, and can be removed and acidified in one step by hydrochloric acid, which reduces the steps of repeated removal of the protective group, and reduces the use of alkali to remove the protective group in the previous process. The step of acidifying with hydrochloric acid is simple in operation and high in yield. |
| priorityDate | 2019-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 60.