http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112142802-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-18 |
| filingDate | 2018-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112142802-B |
| titleOfInvention | Preparation method of fondaparinux sodium |
| abstract | The invention discloses a preparation method of fondaparinux sodium, which comprises a synthesis method of a monosaccharide intermediate 1, 6-dehydration-3-O-benzyl-beta-L-idopyranose, wherein the synthesis method comprises the steps of taking 1, 2-O-isopropylidene-3-O-benzyl-alpha-D-glucopyranose as a raw material, carrying out esterification reaction with benzoic acid, carrying out esterification reaction with substituent sulfonic anhydride and/or substituent sulfonyl chloride, carrying out hydrolysis reaction and adding sulfuric acid aqueous solution for reaction to obtain a fondaparinux sodium monosaccharide fragment intermediate 1, 6-dehydration-3-O-benzyl-beta-L-idopyranose, and the synthesis method has the advantages of simple process, less side reaction impurities and high yield, is suitable for the process amplification synthesis to meet the industrial production of fondaparinux sodium. |
| priorityDate | 2018-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 184.