| abstract |
The present invention relates to a modified antifreeze protein having the chemical formula AFP-PEG, wherein AFP is an antifreeze protein, PEG is a poly(alkylene glycol) group, and PEG is linked to an amino acid in AFP that does not participate in thermal hysteresis, and its side chain Has a functional group selected from the group consisting of amine, thiol, hydroxyl, carboxylate, amide and guanidine. The invention also discloses the chemical formula of the modified antifreeze protein, a method for using the modified antifreeze protein to protect biological tissues, organs or bodies, and a method for synthesizing the modified antifreeze protein. |