http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112125970-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-605 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-605 |
| filingDate | 2020-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112125970-B |
| titleOfInvention | Synthesis method of semaglutide |
| abstract | The invention relates to a synthetic method of semaglutide. Which comprises the following steps: 1) glycine of Fmoc protected alpha amino is coupled on solid-phase synthetic resin, Fmoc protecting group is removed, and then coupling is carried out in sequence according to the method of coupling Fmoc or Boc protected amino acid or peptide segment of alpha amino and then removing Fmoc protecting group; 2) removing the X protecting group in Lys (X); 3) coupling Fmoc-AEEA-OH, and then sequentially coupling Fmoc-AEEA-OH, Fmoc-Glu-OtBu and mono-tert-butyl octadecanedioate by a method of removing Fmoc protecting groups and then coupling; 4) cracking the resin and the side chain protecting group to obtain crude peptide; 5) and purifying to obtain the semaglutide protamine. The method provided by the invention has the advantages of simple process, low cost and high yield. |
| priorityDate | 2020-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 126.