http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112125838-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D261-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-45 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D261-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-42 |
| filingDate | 2020-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112125838-B |
| titleOfInvention | Trifluoromethylated aniline compound and application thereof |
| abstract | The invention provides a trifluoromethylated aniline compound shown as a formula (I) and a preparation method and application thereof. The invention carries out trifluoromethylation modification on the compound such as aminoglutethimide and the like, has simple operation process, and easily obtains the commercialized raw materials; after modification, the anti-tumor activity, particularly the anti-cervical cancer activity, of the compound (Ia) is remarkably improved, and particularly the anti-tumor activity of the compound (Ia) is improved by more than 1 time compared with the anti-tumor activity of aminoglutethimide. Compared with the prior aniline drug modification method, the trifluoromethylation modification method adopted by the invention is more direct, efficient and rapid. |
| priorityDate | 2020-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 72.