http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112121162-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4b3f28ef8ae3d5318b24a9311382f4db http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b188d8faf09bd37ae9848b85b98e833b |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2430-36 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6925 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L24-0015 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L24-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L24-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L24-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-69 |
| filingDate | 2020-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0b7bfb990d7e7f27ba3a0c19b8e3fe72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f1c3af61c8f4cacd3e1be4ba7684662 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e7844114c24ec70285b0420043930c5b |
| publicationDate | 2020-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112121162-A |
| titleOfInvention | A kind of carboxymethyl chitosan microcapsules co-loaded with chemotherapeutic drugs and hyperthermia sensitizers for sustained-release embolization and its preparation method and use |
| abstract | The invention discloses a microcapsule with a chemotherapeutic drug and a hyperthermia sensitizer and a preparation method thereof. The diameter of the microcapsule is 0.5-250 μm, and the thickness of the shell of the microcapsule is 0.05-30 μm. The microcapsule with chemotherapeutic drugs and hyperthermia sensitizers of the present invention comprises a shell and a core material, the shell is carboxymethyl chitosan, the shell is wrapped with a core material, and the core material includes a photothermal sensitizer. For sensitizers and chemotherapeutic drugs, targeting molecules are coupled to the outer surface of the shell. The microcapsules of the present invention are prepared according to the following steps: emulsification, interfacial polymerization, folic acid coupling and washing, so as to obtain materials for encapsulating photothermal heating and tumor embolism. The microcapsules prepared by the patent of the present invention have simple process, good repeatability, high production efficiency, and are easy to realize large-scale production. The particle size, size and thickness of the microcapsules prepared by the invention are controllable. The shell material contains a large number of amino groups, which can endow drugs with functions such as controlled release and antibody conjugation. The microcapsule is a carboxymethyl chitosan microcapsule carrier with photothermal sensitization, slow and controlled release of chemotherapeutic drugs, good targeting and biocompatibility, and has good performance as an embolic agent in breast cancer treatment. application prospects. |
| priorityDate | 2020-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 104.