abstract |
The invention relates to the field of biological cells, in particular to PTPN2-blocking immune cells and applications and preparations thereof. The PTPN2-blocking immune cells express chimeric antigen receptors, and the PTPN2 function in the immune cells is blocked, and the PTPN2-blocking immune cells can secrete anti ‑PD‑1 antibody. Tumoricidal ability and methods for reversing depletion. The invention innovatively combines the function of blocking PTPN2 with CAR and anti-PD-1 immune regulation, so as to improve the tumoricidal activity of immune cells, so as to achieve the effect of curing tumors. |