http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112110872-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-68 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-40 |
| filingDate | 2020-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112110872-B |
| titleOfInvention | A kind of cephalosporin active ester intermediate and continuous preparation method thereof |
| abstract | The invention relates to a cephalosporin active ester intermediate and a continuous preparation method thereof. The raw materials of the intermediate include a raw material acid, dibenzothiazole disulfide, an alkali and a condensation agent; in terms of molar weight, the raw material acid: diphenyl disulfide And thiazole=1:(1-1.5), raw material acid: base=1:(0.3-1.5), raw material acid: condensing agent=1:(1.0-1.5). It is prepared continuously by means of multiple reactors connected in series, and a high-quality cephalosporin active ester intermediate is used as a seed crystal in the reaction bottom material, and at the same time, HPLC is continuously used to detect the reaction process during the continuous process. Compared with the prior art, the invention has the advantages of stable product quality, controllable particle size, controllable reaction process, high reaction efficiency, simple operation, stable operation and low cost. |
| priorityDate | 2020-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 67.