http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112110845-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-12 |
| filingDate | 2019-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112110845-B |
| titleOfInvention | Synthesis method of bazedoxifene and analogues thereof |
| abstract | The invention provides a method for synthesizing bazedoxifene and analogues thereof, which takes simple and easily-obtained initial raw materials as the beginning of a synthetic route and does not need to prepare a compound with amino groups such as-Ac, -NO and-NH in advance 2 N-substituted anilines with isodirecting groupsThe oxidant used in the reaction process has double functions, not only has oxidation function, but also can realize in-situ formation of-NO guide groups, avoids using excessive metal compounds as the oxidant, reduces the synthesis cost and the post-treatment difficulty, and meets the requirement of green chemistry; the reaction temperature is relatively mild, large-scale tests are facilitated, and the obtained product has high purity. The invention realizes a method for synthesizing bazedoxifene and analogues thereof, which is easy to operate, good in atomic economy, high in selectivity, environment-friendly, novel and practical, provides a structure synthesis which is suitable for being provided with a core class with bazedoxifene, and is beneficial to research and development of lead compounds. |
| priorityDate | 2019-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 89.