http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112094281-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C277-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C277-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C279-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-546 |
| filingDate | 2020-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112094281-B |
| titleOfInvention | Preparation method of cefepime hydrochloride for injection |
| abstract | The invention discloses a preparation method of cefepime hydrochloride for injection, belonging to the field of pharmacy and comprising the following steps: adding cefepime hydrochloride and arginine into methanol and purified water respectively, controlling the temperature, and stirring until the mixture is clear; b, filtering the cefepime hydrochloride dissolved solution to a crystallizer, washing and combining filtrate and washing liquor, filtering the arginine dissolved solution, washing and combining the filtrate and the washing liquor for later use; c, adding a mixed solution of acetone and ethanol into the crystallizer, and controlling the temperature; d, adding the arginine dissolving solution and the washing solution under rapid stirring, mixing, controlling the temperature, and growing the crystals; e, adding the mixed solution of acetone and ethanol for the second time after the crystal growing is finished, cooling and growing the crystals; f, after the crystal growing is finished, filtering, washing and drying the crystal to obtain a raw material medicine; and g, subpackaging the raw material medicaments into cefepime hydrochloride products for injection. The invention ensures the high level of the mixing uniformity of the product, effectively improves the quality of the cefepime hydrochloride product for injection and further ensures the medication safety. |
| priorityDate | 2020-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 42.