http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112094229-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c806892c768c1ade2e5f1bdcf14e66f7 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-02 |
| filingDate | 2020-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e507706e2608279c9f5ea11ced79cd4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_03a426b008b05818aa13d24cace1d9b3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a7bcdac58b1705068810f2affe516c48 |
| publicationDate | 2020-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112094229-A |
| titleOfInvention | Synthetic method of 6-(trifluoromethyl)isoquinolin-5-ol |
| abstract | The invention discloses a method for synthesizing 6-(trifluoromethyl)isoquinoline-5-alcohol, which takes p-trifluoromethylphenethylamine as a raw material, undergoes amino protection, ring closure, hydrolysis, bromine and TFAA with TFAA. Generation, debromo-vinylate and dehydroaromatization to obtain 7-trifluoromethyl isoquinoline, carry out 5-position bromination with NBS to generate 5-bromo-7-trifluoromethyl isoquinoline, and carry out methylation with sodium methoxide. Oxylation and demethylation give 6-(trifluoromethyl)isoquinolin-5-ol. The invention has simple synthetic route, reasonable process selection, low cost of raw materials, simple and readily available raw materials, convenient operation and post-processing, high total yield, no use of highly toxic reagents, easy scale-up, and large-scale production. |
| priorityDate | 2020-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 83.