http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112089892-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2430-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-602 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-622 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-412 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2400-12 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3604 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3687 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-54 |
| filingDate | 2020-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112089892-B |
| titleOfInvention | Bionic modified valve material and preparation method and application thereof |
| abstract | The invention discloses a bionic modified valve material and a preparation method and application thereof, comprising the following steps of A, synthesizing drug-loaded nanoparticles; B. preparing cell membrane vesicles; C. mixing the drug-loaded nanoparticles with the cell membrane vesicles and extruding for multiple times to prepare drug-loaded nanoparticles wrapped by cell membranes; D. and (3) crosslinking the drug-loaded nanoparticles wrapped by the cell membrane to the surface of the biological valve to obtain the drug-loaded nano-particles. The method has the advantages of simple operation, mild reaction conditions and the like, and the bionic modified valve material with the cell membrane coated with the nano drug-loaded particles can well solve the problems of easy thrombosis, calcification, difficult endothelialization and the like of the existing glutaraldehyde cross-linked valve. Meanwhile, a strategy of combining a cell membrane bionic drug delivery system with a valve provides a new generation of treatment mode for safe and efficient treatment of valvular heart disease. |
| priorityDate | 2020-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 33.