http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112079724-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f71c3ff228c6a2f9942174660497a9d9 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C209-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-40 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-29 |
| filingDate | 2020-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d5d076a249ff81e19f5c872c477a13c4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc749d2f73849755c6896c91c3864953 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_edf8441838ff351ff26fefa4da8da8b0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f4fb4d4ac21752fc7b7fbd54b24d2165 |
| publicationDate | 2020-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112079724-A |
| titleOfInvention | A kind of preparation method of deshydroxy mirabegron and intermediate thereof |
| abstract | The invention relates to a preparation method of deshydroxy mirabegron and an intermediate thereof. In the present invention, the key intermediate N-(4-nitrophenylethyl)-2-, the key intermediate N-(4-nitrophenylethyl)-2-, is obtained by reacting (2-haloethyl) benzene with 4-nitrophenethylamine Phenylethylamine. In addition, the present invention provides a preparation method of dehydroxy mirabegron, comprising the following steps: (1) (2-haloethyl)benzene reacts with 4-nitrophenethylamine to obtain N-(4 -nitrophenylethyl)-2-phenethylamine, and then reduction to obtain 4-[2-(phenylethylamino)ethyl]aniline, and finally react with 2-aminothiazole-4-acetic acid to obtain Hydroxymirabegron. Finally, the present invention provides a method for preparing high-purity dehydroxymirabegron, which satisfies the increasing demand for impurity reference substances. The technical solution of the present invention solves the problem that starting materials are difficult to obtain, adopts low-cost starting materials, and in addition, has a short route, does not need to use hydrogen, is simple in operation, has mild reaction conditions, and is suitable for production. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113480455-A |
| priorityDate | 2020-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 89.