| abstract |
The invention discloses a method for constructing carboxylic acid or alcohol by olefin remote functionalization. The method comprises the following steps: (1) mixing an olefinic compound, a photocatalyst, a base, and a radical precursor; dissolving the obtained solid phase mixture in a nitrogen atmosphere, filling carbon dioxide after freezing and degassing, and then stirring for 2-10 min; or adding aldehyde or ketone into the obtained solid phase mixture, dissolving in a nitrogen atmosphere, freezing, degassing, filling nitrogen, and stirring for 2-10 min; (2) then, under the condition of room temperature, blue light is adopted for irradiation reaction for 2-30 h; after the reaction is finished, diluting with ethyl acetate, then quenching with hydrochloric acid, then extracting with ethyl acetate, and purifying after rotary evaporation and concentration to obtain the carboxylic acid or alcohol. The synthetic method of the invention has good reactivity for activated olefin and non-activated olefin substrates, and the yield of the target product is high. |