http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112063655-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6b0bfa2cfb7717b11b95f9c528a1be31 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10043 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y207-07049 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1276 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P39-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-45 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-861 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P39-06 |
| filingDate | 2020-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f676129c8013f34cdc58f17a0e4c3717 |
| publicationDate | 2020-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112063655-A |
| titleOfInvention | A telomere gene therapy product and use of a mammalian broad promoter |
| abstract | In human cells, each time the cell divides, the telomeres at the top of the chromosomes shorten once. When the telomeres can no longer be shortened, the cell cannot continue to divide. At this time, the cell also turns on the apoptosis signaling pathway. Considered as the "clock of life", telomeres not only protect the stability of chromosomes, but also play an important role in recognizing the starting point of cell renewal and division. The length of telomeres achieves the functions of promoters and silencers, and regulates the expression of proteins downstream of chromosomes. Aging has various associations, and prolonging telomeres is very important for healthy reversal of aging. This invention uses an adenovirus gene therapy vector to take advantage of gene replication defects to control the activity of telomerase and avoid the risk of carcinogenesis. Through the adenovirus gene therapy vector, the telomeres of human cells are prolonged, the number of divisions of each cell in the human body is increased, the expression of aging-related genes is inhibited, and the expression of youth-related genes is activated, so as to achieve the therapeutic effect of reversing aging and prolonging lifespan. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115458063-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115458063-B |
| priorityDate | 2019-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 189.