http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112062859-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-7051 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P33-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 |
| filingDate | 2020-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-08-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-08-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112062859-B |
| titleOfInvention | Chimeric antigen receptors for pathogen clearance and their applications |
| abstract | The present invention provides a chimeric antigen receptor (Chimeric Antigen Receptor, CAR) polypeptide against pathogens, which has: (a) an extracellular domain, including one or more pathogen-associated antigen-specific antigen binding regions; (b) ) transmembrane domain; (c) at least one copy of the intracellular signaling domain of the "eat-me" signaling receptor capable of specifically binding pathogen antigens and activating endogenous silent phagocytic clearance signals. Further, the present invention also provides polynucleotides encoding the polypeptides, gene vectors, recombinant cells carrying chimeric antigen receptors, and compositions. The chimeric antigen receptor characteristically mediates the phagocytosis and clearance of pathogens by recombinant cells without significant release of cytokines, in fact achieving a "silent" pathogen clearance mode. |
| priorityDate | 2020-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1075.