http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112062841-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-4748 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6854 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-553 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K17-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-54346 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P39-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-543 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-553 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K17-14 |
| filingDate | 2020-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112062841-B |
| titleOfInvention | Polypeptide and preparation method thereof, artificial antibody against p53 protein and application thereof |
| abstract | The invention discloses a polypeptide design and preparation method, an anti-p53 protein artificial antibody and applications thereof. Invented a method of grafting two CDR loop fragments of natural antibodies onto nanoparticles at the same time, splicing the two CDR loop fragments of natural antibodies into a polypeptide through a cysteine, and adding one more at both ends Cysteine: The designed polypeptide has 3 cysteines, which can form a 3-point fixation with nanoparticles, thereby forming an M-shaped structure, simulating the correct relative position and conformation of the two CDR loops of natural antibodies and jointly completing the recognition of antigens Function. The invention relates to a gold nano-antibody targeting p53 protein, which is obtained from a designed polypeptide-modified gold nano-particle composed of two CDR loops spliced together. The gold antibody can specifically target p53 protein. The novel gold nano-antibody of the present invention can specifically recognize the p53 protein, and when the concentration of the p53 protein is very low, the gold antibody can still maintain a high binding affinity with the protein. |
| priorityDate | 2020-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 97.