http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112062767-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-16 |
| filingDate | 2020-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112062767-B |
| titleOfInvention | Preparation method and intermediate of rumepilone |
| abstract | The invention provides a preparation method of rumepilone and an intermediate thereof, which comprises the step of using 6-bromo-2, 3,4, 5-tetrahydro-1H-pyrido [4,3-b ]]Indole compound 1 is used as an initial raw material to obtain a compound 2, then Boc protection is carried out to obtain a compound 3, then the compound 3 and 2-chloro-N-methylacetamide are firstly carried out to obtain a compound 4, and then intramolecular Ullmann coupling reaction is carried out to cyclize the compound to obtain a compound 5; reducing the compound 5 by using borane to obtain a compound 6, then removing Boc protection and salifying to obtain a mepiquat chloride key intermediate compound 7, or reducing and deprotecting by a one-pot method and salifying to obtain an intermediate compound 7; an intermediate compound 7 and a compound 8 are subjected to reductive amination condensation to obtain a compound 9, and finally the compound is reacted with a 4-fluorophenyl Grignard reagent to obtain a Lumepigron product compound 10, wherein the reaction route is as follows: |
| priorityDate | 2020-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 135.