| abstract |
The present application relates to substantially surfactant-free submicron dispersions comprising hydrophobic agents of high levels of water-miscible solvents. Compositions for administration to human or animal skin, hair, or external mucosa and methods of using the compositions are provided. The compositions include, for example, compositions for application to skin, hair or external mucosa comprising: a) dispersed submicron particles of a hydrophobic agent having an average particle size of 100 nm to 999 nm; b) an aqueous solvent fluid; and c) A rheology modifier; wherein the aqueous solvent fluid is 10% to 95% by weight of one or more water-miscible solvents, 4.99% to 89.99% by weight water, and 0.01% to 10% by weight and wherein the hydrophobic agent constitutes from 0.01% to 70% by weight of the skin, hair or mucosal composition; and wherein the composition is substantially free of surfactants. |