| abstract |
The invention discloses a 1,4-diolefin compound and a preparation method and application thereof. In the present invention, (0.2-8) mmol of allyl alcohol, (0.6-24) mmol of olefin, (0.006-0.4) mmol of tetrakis(triphenylphosphine) palladium, (0.02-0.8) mmol of calcium bisimide, ( 0.02-0.8) mmol potassium hexafluorophosphate was added to (2-40) mL of reaction solvent in turn, and the reaction was stirred under inert gas atmosphere and 90-110 ° C for 12-24 h to obtain a reaction solution, and the reaction solvent of the reaction solution was removed. , and then purified by thin-layer chromatography, and the developing solvent system is petroleum ether/ethyl acetate to obtain 1,4-diolefin compounds. The method of the invention has the characteristics of a wide range of applicable substrates, low preparation cost and convenient operation, and the obtained by-product is only water, which is green and environmentally friendly. The obtained 1,4-diene compounds can be used as biological and pharmaceutical active molecular skeletons and have wide application prospects. |