| abstract |
The invention discloses a polysubstituted vinyl compound, a preparation method and application thereof. The invention specifically discloses a preparation method of a polysubstituted vinyl compound shown in formula III, which comprises the following steps: in an organic solvent, the compound shown in formula I and the compound shown in formula II are mixed in a palladium catalyst, a phosphine In the presence of a ligand and a base, the reaction shown below can be carried out to obtain a polysubstituted vinyl compound represented by formula III. The preparation method can be applied to various types of substrates, and the configuration of the double bond is controllable. |