http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112028856-A
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c6e89a563fdd790eb33d66f1290570d9 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-192 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-192 |
filingDate | 2019-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_74d771134b9d97727c8c005c92c22e1f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2b1c42c8226554e42d6ad22f31c8598f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_021f1a66dbf24b8445328d9889d2308e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b7d4b6977e04b458908208c8780bc008 |
publicationDate | 2020-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-112028856-A |
titleOfInvention | Preparation method of cinepazide maleate intermediate |
abstract | The invention provides a preparation method of a cinepazide maleate intermediate, which comprises the following preparation steps: taking (E) 3,4, 5-trimethoxy cinnamoyl chloride and diethanol amine as starting raw materials, reacting under the action of alkali to generate an intermediate c, (E) N, N- (2-hydroxyethyl) -3,4, 5-trimethoxy cinnamamide, chlorinating hydroxyl under the action of thionyl chloride to obtain an intermediate d (E) N, N- (2-chloroethyl) -3,4, 5-trimethoxy cinnamamide, and reacting with E alpha-aminoacetyl pyrrolidine to generate cinepazide. The synthetic route of the invention has the advantages that: (1) all raw materials are low in cost and are easy to obtain in the market; (2) greatly simplifies the post-treatment steps of the process, is easy to control, can realize industrial production and reduces the process cost. |
priorityDate | 2019-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 60.