| abstract |
The application relates to the technical field of chemical pharmacy, in particular to a method for synthesizing 3',5'-dichloro-2,2,2-trifluoroacetophenone, by first synthesizing 1,3,5-trichlorobenzene Or 3,5-dichloro-1-bromobenzene reacts with magnesium to form Grignard reagent in that trifluoroacetyl reagent undergoes nucleophilic addition reaction, and after acid treatment, 3',5'-dichloro-2,2, 2-Trifluoroacetophenone has mild reaction conditions, low cost of raw materials, good economic effect and wide industrial production prospects. |