http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112010984-B
Outgoing Links
Predicate | Object |
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classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2770-20034 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2770-20022 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-195 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-215 |
filingDate | 2020-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2021-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2021-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-112010984-B |
titleOfInvention | Novel coronavirus S protein polymer nano vaccine based on helicobacter pylori ferritin |
abstract | The invention discloses a novel coronavirus S protein subunit nano vaccine based on helicobacter pylori ferritin. The invention uses Receptor Binding Domain (RBD) expression protein of novel coronavirus and N end of helicobacter pylori polymer protein (HP _ Ferritin, HPF) to form subunit polymer protein through intermolecular isopeptide bond effect in a SpyTag/Spycatcher (ST-SC) system, thus realizing antigen multimerization; or the RBD expression protein and a Heptad Repeat (HR) expression protein are combined with the HPF protein by ST-SC covalent binding to form a double subunit polymer protein, so as to realize antigen multimerization. The scheme can overcome the defect of insufficient immunogenicity of RBD monomers, the obtained vaccine can remarkably improve the level of neutralizing antibodies of a host to viruses, and the generated antibodies have the capacity of powerfully blocking the viruses from invading target cells. Meanwhile, based on sequence analysis, the scheme of the invention is expected to develop effective vaccines aiming at various coronaviruses. The vaccine of the invention has simple preparation method, easy purification and high safety, and can be quickly applied to clinical tests. |
priorityDate | 2020-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 555.