| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_da8c47b46efd30a3c00063f9b10bacbb |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1033
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1037 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-6428
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K11-06 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09K11-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-16 |
| filingDate |
2020-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8fa191a464ffc3b6af00b26bc830668f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa445ea1f3e820cecf12d6d0012fcf47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e51f83e9859b0e891fa7eea05f38e6ac
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc1947729eca0cff7ebd9921acbf43a0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c60cbca6f1af194896a8b677b0c5467d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_454c8d8901695d9f16bfe7ab585c6d03
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e94cabb4d2b64e06f35f7786fda8f16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_65dfc9310b4f81ea71fb38b232d00c03 |
| publicationDate |
2020-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-112010865-A |
| titleOfInvention |
A small molecule fluorescent probe for detecting hypochlorous acid and its preparation method and application |
| abstract |
The invention discloses a small molecule fluorescent probe for detecting hypochlorous acid, a preparation method and application thereof, and relates to the technical field of biological detection. The preparation method of the fluorescent probe of the present invention is to react 8-hydroxy-nonaronidine-9-formaldehyde shown in formula (II) with ethyl acetate and piperidine in alcohol to obtain the coumarin shown in formula (III) and then in an inert atmosphere, the coumarin derivative shown in formula (III) reacts with methanesulfonic acid and 2-mercaptoethanol in an organic solution to obtain the compound shown in formula (I), namely this Invented fluorescent probes. The fluorescent probe of the invention has high selectivity and sensitivity, and can be used for the detection of the small molecule fluorescent probe of hypochlorous acid in the detection of exogenous hypochlorous acid in living cells and the fluorescence imaging of the dynamic change of HOCl in inflammatory cells. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113307788-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115417881-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114736195-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114736195-B |
| priorityDate |
2020-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |