| abstract |
The invention provides a method forA polarity conversion promoter of anti-inflammatory M2 phenotype microglia. The promoter of polar transformation into anti-inflammatory M2 phenotype microglia cells comprises a cyclic peptide derivative represented by formula (1). Wherein m is 0 to 3, n is not less than 1, R 1 ～R 6 Is a hydrogen atom or a hydrocarbon group, R 7 、R 8 Is carboxy or a salt thereof or alkoxycarbonyl, R 9 Is a hydrocarbon group, a hydroxyl group, an alkoxy group or an alkylcarbonyloxy group, R 10 And R 11 Is a hydrogen atom, a hydrocarbon group or an alkylcarbonyloxy group, R 12 ～R 16 Is a hydrogen atom or a hydrocarbon group. [ chemical formula 1] 。 |