| abstract |
The invention discloses a cilostazol liposome solid preparation which is prepared by the following steps: dissolving cilostazol in acetic acid, and mixing dioleoylphosphatidylcholine, dimyristoylphosphatidylcholine, poloxamer P188 and cholesterol succinic acid monoester to form lipid membrane solution; adding acetic acid-sodium acetate buffer solution, and dispersing and emulsifying; adding lactose, sodium carboxymethyl starch, microcrystalline cellulose and magnesium stearate, mixing, and refining and dispersing; and (5) freeze drying. The invention improves the drug loading capacity of cilostazol and the encapsulation rate of cilostazol liposome, simultaneously has simpler preparation method, shortens the process flow and has safe and nontoxic raw materials in the production process. |