| abstract |
The invention relates to the field of biological materials, in particular to a biologically active three-dimensional nanofiber scaffold. The material of the biologically active three-dimensional nanofibrous scaffold is biologically active three-dimensional nanofibers, and the biologically active three-dimensional nanofibers include hydroxyapatite doped A nanofiber matrix of stone and a chitosan layer and a gelatin layer wrapped on the surface of the nanofiber matrix, a bone scaffold comprising the bioactive three-dimensional nanofiber scaffold and the bioactive three-dimensional nanofiber Growth factor layer on the surface of the fibrous scaffold. The bone scaffold prepared by the invention can simulate the structure of extracellular matrix, and can release growth factors and trace elements slowly at the same time, so as to provide a good microenvironment and induction effect for tissue regeneration and repair, and is especially suitable for regeneration and repair of bone tissue defects. |