| abstract |
The invention discloses a drug delivery method of doxycycline hydrochloride and florfenicol to respiratory pathogenic bacteria based on a PK/PD model, which comprises the following steps that doxycycline hydrochloride and florfenicol respectively have optimal combined drug ratio to actinobacillus pleuropneumoniae and haemophilus parasuis, under the optimal combined drug ratio to the doxycycline hydrochloride and the florfenicol, the doxycycline hydrochloride and the florfenicol are used for detecting the in vitro drug sensitivity to the actinobacillus pleuropneumoniae and the haemophilus parasuis under the independent and combined conditions, and the distribution of MIC is counted; the doxycycline hydrochloride and florfenicol injection is prepared into a dosage scheme of the actinobacillus pleuropneumoniae and the haemophilus parasuis for preventing, treating and eradicating diseases, and finally the dosage scheme of the component with smaller therapeutic dose in the combined medicine components is taken as a final dosage scheme. |