http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111983055-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-8679 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-60 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-34 |
| filingDate | 2020-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111983055-B |
| titleOfInvention | Method for separating and measuring rivaroxaban intermediate related substances by using HPLC (high performance liquid chromatography) |
| abstract | The invention provides a method for separating and measuring related substances of rivaroxaban intermediates by using HPLC (high performance liquid chromatography), which comprises the following steps of: octadecylsilane chemically bonded silica is used as a filling agent, 0.01-0.03 mol/L potassium dihydrogen phosphate solution (the pH value is adjusted to 5.0-8.0 by sodium hydroxide) is used as a mobile phase A, acetonitrile or methanol or acetonitrile-methanol is used as a mobile phase B for gradient elution, the flow rate is 0.8-1.2 ml/min, the column temperature is 25-40 ℃, and related substances of the rivaroxaban intermediate are detected by an ultraviolet detector. The method comprehensively considers the analysis column, the mobile phase, the gradient elution program, the flow rate and the comprehensive influence of the column temperature on the separation detection, optimizes the detection result, has the advantages of rapidness, simplicity, convenience, high sensitivity, accuracy, reliability and wide applicability, and is suitable for separating and determining related substances of rivaroxaban intermediates, thereby effectively controlling the quality of the medicine. |
| priorityDate | 2020-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 38.