http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111979271-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a54d45f650d3929454b9bd36dc71f4ae |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-03 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-89 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0276 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-89 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 |
| filingDate | 2020-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_25a59aa9cc1059ccdec4bf679d72e5d1 |
| publicationDate | 2020-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111979271-A |
| titleOfInvention | Method for preparing Bietti crystal-like atrophy non-human mammal model and application thereof |
| abstract | The invention relates to the technical field of molecular biology and biomedicine, in particular to a method for preparing a Bietti crystal-like atrophy non-human mammal model and application thereof. The method comprises knockout of the first exon of the animal CYP4V3 gene knockout transcript using the criprpr-Cas system. The eyeground of the animal model prepared by the invention has typical yellowish-white crystal deposition in 7 months, while the existing model can only have typical crystal deposition in at least 12 months, and the model is beneficial to the development of experimental research as soon as possible in the time dimension; meanwhile, the atrophy of the outer nuclear layer appears in the natural course of the animal model within 12 months, corresponding to the extinction of a wave and b wave in ERG, but the atrophy of the outer nuclear layer does not appear in the followed course of the disease in the prior model, so that the model better simulates the decline of the visual function of a BCD patient and is more beneficial to the exploration of the pathological mechanism of the BCD. |
| priorityDate | 2020-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 249.