http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111978336-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9ec6a5f829269f9f9104f4828f0a306f |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F1-005 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F1-08 |
| filingDate | 2020-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_50bf1577e67782b74d2c4fad8ee934ef http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_954d2b43cd71dc84fc9ef13c8f46911a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f180b1770754324c3cd5acae8847f56c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e68e523a2f0552cb3788c5a779e7bbcb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_df591b1a6f01e19cec42a5044aaf6db8 |
| publicationDate | 2020-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111978336-A |
| titleOfInvention | Preparation method and application of 5-fluorouracil-1-ylacetic acid o-phenanthroline copper tetrafluoroborate anticancer functional complex |
| abstract | The invention discloses a preparation method and application of a 5-fluorouracil-1-ylacetic acid o-phenanthroline copper tetrafluoroborate anticancer functional complex. The invention provides a method for synthesizing a novel Cu complex [Cu(phen) 2 L1]BF 4 ·H 2 O (phen=1,10-phenanthroline, L1=5-fluorouracil-1-ylacetic acid), and characterize. The crystal structure of the complex was analyzed by X-ray diffraction single crystal structure and differential thermal analysis, and the results showed that the complex has a certain stability at ambient temperature. The binding of the complexes to CT-DNA was studied by UV-Vis absorption spectroscopy, fluorescence spectroscopy and electrochemical methods, and the results showed that the complexes had electrostatic interactions with DNA. In addition, in vitro cell experiments, the complex [Cu(phen) 2 L1]BF 4 ·H 2 O can well inhibit the growth of human breast cancer cells and human colon cancer cells. The complex [Cu(phen) 2 L1]BF 4 ·H 2 O can be listed as a promising anti-tumor drug candidate based on the structural modification with bio-friendly metal copper and showing good anti-tumor activity. |
| priorityDate | 2020-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 51.