| abstract |
The present invention provides a pH-responsive therapeutic vaccine based on co-encapsulated antigen and photosensitizer mesoporous silicon nanoparticles, a preparation method and application thereof, and relates to the technical field of therapeutic vaccines. The inventors of the present invention have designed a nano-platform , using mesoporous silica nanoparticles as a carrier, co-loading photothermal therapeutic agent dopamine and thiolated antigen for photothermal combined immunotherapy of tumors. Through the preparation method provided by the present invention, a pH-responsive therapeutic vaccine based on mesoporous silicon nanoparticles co-encapsulated with antigen and photosensitizer is obtained, and the encapsulation rate of the antigen is as high as 92.20%. At the same time, the preparation method has simple process and convenient operation, can be realized without expensive instruments or high-end technicians, has low cost, and is suitable for popularization and application. |