http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111948401-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-2835 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6851 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6887 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6851 |
| filingDate | 2020-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111948401-B |
| titleOfInvention | Application of CHCHHD 10 in promotion of AChR subunit gene expression and maintenance of NMJ stability |
| abstract | The invention discloses application of CHCHHD 10 in promoting AChR subunit gene expression and maintaining NMJ stability. The invention explores the regulation and control effect of CHCHD10 in skeletal muscle on NMJ homeostasis by experimental technical means such as immunohistochemistry, electrophysiology, electron microscopy and ethology; silencing or knocking out the CHCHHD 10 gene can cause the ATP level of cells or tissues to be reduced, and the ATP generation is dependent on the expression of CHCHHD 10; it was also further demonstrated that ATP can promote Agrin-induced AChR aggregation; the ATP can promote the combination of the transcription factor GABP alpha and the promoter of the AChR subunit gene through a chromatin immunoprecipitation experiment; this suggests that ATP promotes AChR subunit gene expression, and further promotes Agrin-induced AChR aggregation, thereby maintaining normal NMJ function; the present invention suggests that targeting NMJ may be an important tool for early treatment and intervention in ALS and other neuromuscular diseases. |
| priorityDate | 2019-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 217.