| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-73
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-56 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-241
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2818
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-13
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate |
2020-08-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2022-02-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2022-02-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-111944052-B |
| titleOfInvention |
anti-TNF-alpha/PD-1 bispecific antibody and application thereof |
| abstract |
The invention discloses an anti-TNF-alpha/PD-1 bispecific antibody and application thereof. The invention uses anti-human PD-1 antibody and anti-human TNF-alpha antibody to construct a bispecific antibody, the bispecific antibody can neutralize TNF-alpha promoting tumor cell proliferation, and simultaneously is combined with PD-1 to block PD-1/PD-L1 signals between tumor cells and T cells, thereby effectively killing tumor cells and having good biological activity and application prospect. |
| priorityDate |
2020-08-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |