http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111944006-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J9-00 |
| filingDate | 2014-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111944006-B |
| titleOfInvention | Novel 7-keto-6β-alkylcholanoic acid derivatives in the preparation of obeticholic acid and its use in the field of medicine |
| abstract | The invention belongs to the fields of organic synthesis and medicinal chemistry, and provides a new 7-keto-6β-alkyl cholanoic acid derivative for preparing obeticholic acid and uses thereof in the medical field. In the present invention, 7-keto-6β-alkylcholanoic acid derivatives shown in formula II are used as raw materials, and 6α configuration is converted into 6β configuration under acid or alkali conditions to prepare 7-keto-6α-alkylcholanoic acid Alkanoic acid derivatives. The present invention also provides 7-keto-6β-alkyl cholanoic acid derivatives and the use thereof for preparing 3α,7α-dihydroxy-6α-alkyl-5β-cholanoic acid. The preparation method involved in the present invention is easy to operate, has high configuration conversion rate, and the product 7-keto-6α-alkylcholanoic acid derivative is easy to purify, and the preparation of 3α, 7α-dihydroxy-6α-alkyl-5β-cholanoic acid is reduced. Difficulty in purifying alkanoic acids. |
| priorityDate | 2014-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 96.