| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-414
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-102
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2400-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08J2305-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-602
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2430-02 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08J3-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-227
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08J3-075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-025 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08J3-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08L5-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08J3-075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-02 |
| filingDate |
2020-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2022-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2022-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-111939325-B |
| titleOfInvention |
Injectable composite hydrogel and preparation method and application thereof |
| abstract |
The invention discloses an injectable composite hydrogel and a preparation method and application thereof. The preparation method comprises the following steps: 1) preparing a natural polysaccharide material solution; 2) preparing a glycerophosphate solution; 3) preparing a four-arm polyethylene glycol succinimide carbonate solution; 4) preparation of T4 Lysozyme/Zn 2+ A protein solution; 5) uniformly mixing the solutions prepared in the steps 1), 2), 3) and 4), and incubating to obtain the injectable composite hydrogel. The preparation method of the invention can realize gelation by quickly forming through click chemical reaction and operating under physiological conditions, and has the advantages of short gelation time, mild reaction conditions and controllable gelation performance. The hydrogel prepared by the invention can be applied to tissue engineering materials, and is particularly suitable for local cavity filling materials of bone defects. |
| priorityDate |
2020-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |