| abstract |
The invention discloses a class of magnetic-targeting cell membrane modifying ligands, drug-loaded materials and their preparation methods and applications. The magnetic-targeting cell membrane modifying ligands have general structural formulas such as series I or series II in formula (1). shown. In the present invention, the magnetic targeting cell membrane drug-loading material is obtained by chemically covalently modifying the cell membrane with a magnetically targeting cell membrane modifying ligand. In vitro tests show that this type of material has good stability, can be effectively taken up by tumor cells, and is effective against tumor cells. It has high selectivity, and at the same time, this type of material has significant paramagnetism, and can achieve magnetic targeting effect under the condition of external magnetic field. In the in vitro anti-tumor test, this kind of drug-loaded material has significant anti-tumor activity and almost no toxicity to normal cells, indicating that it has the potential use of targeted therapy for malignant tumors. |