http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111925398-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F15-0066 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-555 |
| filingDate | 2020-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111925398-B |
| titleOfInvention | FTO (fluorine-doped tin oxide) small-molecule inhibitor palladium complex and synthesis method thereof |
| abstract | The invention discloses an FTO decimal fractionThe palladium complex of the sub-inhibitor and the synthesis method thereof are that the thiosemicarbazide is dissolved in anhydrous CH 3 OH, adding 2-pyridine formaldehyde, refluxing, filtering, volatilizing filtrate at room temperature to precipitate crystals, and adding anhydrous CH 3 OH washing to obtain a ligand; taking ligand and PdCl 2 Adding anhydrous CH into a round-bottom flask 3 Dissolving OH, carrying out reflux reaction, filtering while the solution is hot, volatilizing the filtrate at room temperature, separating out solids, and recrystallizing by using absolute ethyl alcohol to obtain palladium complex crystals. The invention further performs various tumor cell proliferation inhibition activity experiments on the synthesized palladium complex, performs FTO protein activity test experiments and determines the interaction between the palladium complex and the FTO protein, thereby proving that the palladium complex can be used as an alternative of FTO protein small-molecule inhibitors. The synthesis method is simple to operate and convenient to implement. |
| priorityDate | 2020-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 92.