http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111925369-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1044 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1033 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1088 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-6428 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0057 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0021 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09K11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2020-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111925369-B |
| titleOfInvention | Beta-carboline cyano furan derivatives, preparation method and application thereof |
| abstract | The invention relates to the technical field of biological medicines, in particular to a beta-carboline cyano furan derivative, a preparation method and application thereof, and the beta-carboline cyano furan derivative has a structure shown in a general formula I or II: the structure of the beta-carboline derivative combined with the naturally-occurring indole alkaloid has pyridine [3,4-b ]]And a planar tricyclic framework of indole; five-membered ring cyano furan segments with strong electron withdrawing property are introduced into 1 or 3 positions of the beta-carboline mother ring through Knoevenagel condensation reaction, the conjugated system of the beta-carboline is further prolonged, and two types of beta-carboline cyano furan derivatives with photodynamic effect and pH sensitive fluorescence are designed and obtained by utilizing ICT effect. The compound has the characteristics of high stability, low dark toxicity and the like, can generate high-activity singlet oxygen under laser irradiation, can effectively eliminate tumors, provides an effective tool for monitoring and treating tumors in medicine, and has good application prospects in the aspects of tumor targeted imaging, treatment, monitoring and the like. |
| priorityDate | 2020-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 77.