http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111909245-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-085 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1088 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57484 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57438 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57446 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6893 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-001 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-6486 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57407 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09K11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-20 |
| filingDate | 2020-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111909245-B |
| titleOfInvention | Collagen targeting polypeptide probe containing aromatic amino acid, preparation method and application thereof |
| abstract | The invention belongs to the technical field of collagen detection, and particularly relates to a collagen targeting polypeptide probe containing aromatic amino acids, a preparation method and application. The polypeptide probe provided by the invention is prepared by using the existing GPO polypeptide probe (Gly-Pro-Hyp) n Pro at the middle position was replaced by Tyr or Phe, and two novel polypeptide probes FAM-GYO comprising aromatic amino acids were constructed: FAM- (Gly-Pro-Hyp) 3 ‑Gly‑Tyr‑Hyp‑(Gly‑Pro‑Hyp) 4 And FAM-GFO: FAM- (Gly-Pro-Hyp) 3 ‑Gly‑Phe‑Hyp‑(Gly‑Pro‑Hyp) 4 . The polypeptide probes FAM-GYO and FAM-GFO remarkably reduce the stability of the triple helical structure of the existing GPO probe, maintain the ability of targeted binding of pathological collagen equivalent to that of the existing GPO probe, can specifically bind denatured collagen in different tissues of a mouse, can be successfully applied to tissue staining of different disease samples, and have wide application prospects in the fields of early detection and curative effect evaluation of collagen related diseases such as tumors, fibrosis and the like. Meanwhile, the polypeptide probes FAM-GYO and FAM-GFO are short in length, and complex unnatural amino acids are not introduced, so that the difficulty and cost of probe synthesis are greatly reduced. |
| priorityDate | 2020-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 113.