http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111909242-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08 |
| filingDate | 2020-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111909242-B |
| titleOfInvention | Polypeptide with high affinity and specific binding of beta-catenin protein and application and synthetic method thereof |
| abstract | The invention discloses a polypeptide with high affinity and specific binding to beta-catenin protein, and an application and a synthetic method thereof, wherein the amino acid sequence of the polypeptide is LEHRERSLQT (X1) RDIQRML (X2) P, wherein X1 is leucine, norleucine or homoleucine, X2 is phenylalanine, 1-naphthylalanine, 2-anthrylalanine or 9-anthrylalanine; the polypeptide is used for inhibiting the growth of cancer cells; the polypeptide of the invention can realize various tumor treatment targets; the polypeptide inhibits the opening of a beta-catenin protein mediated Wnt signal path by inhibiting the mutual combination of beta-catenin protein and BCL9 in cancer cells, thereby inhibiting the growth of tumor, inducing the self-apoptosis of cells and realizing the treatment target of tumor diseases; the synthesis method of the polypeptide is simple and easy to obtain, the yield efficiency of the final product is high, the polypeptide has the potential of mass production, and the polypeptide has the potential of clinical drug transformation. |
| priorityDate | 2020-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 97.