http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111905109-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G81-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-713 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-713 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G81-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-64 |
| filingDate | 2020-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111905109-B |
| titleOfInvention | Synthesis and characterization of delivery vector pHLIP-PEI-PLA and research method of siRNA delivery by using same |
| abstract | The invention is suitable for the technical field of cancer treatment, and provides a synthesis and characterization of a transport carrier pHLIP-PEI-PLA and a research method for siRNA delivery, wherein pHLIP-PEI-PLA copolymer is synthesized firstly, the complexation capability of the pHLIP-PEI-PLA copolymer to siRNA is determined, and the serum stability of a pHLIP-PEI-PLA @ siRNA complex is detected; preparing pHLIP-PEI-PLA @ siRNA complexes, observing the uptake condition of cells to the FITC-pHLIP-PEI-PLA @ siRNA complexes, and finally analyzing the uptake condition of the cells to the pHLIP-PEI-PLA @ siRNA complexes through flow cytometry, thereby providing a theoretical basis for researching the efficiency of delivering siRNA to tumor cells by pHLIP-PEI-PLA copolymers and the application of siRNA in tumor treatment. |
| priorityDate | 2020-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.