| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_50eb752940fa4aa36756a6bc9f6f3504 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2440-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B20-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6842
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B20-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6854
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B5-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G06F17-11 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B5-30 |
| filingDate |
2019-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_75e0036ce74a1f95173976bd54ec5cdb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_344c03e6b7c09b5b4db027d31bbafd34 |
| publicationDate |
2020-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-111902874-A |
| titleOfInvention |
Quantification and Modeling of Quality Attributes of Therapeutic Monoclonal Antibodies |
| abstract |
Methods are provided for predicting the in vivo serum concentration of an antibody having a target post-translational modification following administration of the antibody, as well as methods for predicting the exposure of a subject to post-translational variants of the antibody. The method comprises: using the determined in vivo rate constant for the post-translational modification to predict the percentage of the antibody with the target post-translational modification; and using the antibody with the target post-translational modification of the The predicted percentage is multiplied by the in vivo concentration of the antibody to determine the concentration of the antibody with the target post-translational modification. |
| priorityDate |
2018-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |